Abstract Background Hereditary transthyretin amyloidosis (hATTR) is a rare autosomal dominant disease with high clinical variability, influenced by both genotype and the geographic origins of carriers.There is a limited understanding of the Val142Ile and Ser43Asn recognised mutations in Ecuador and Colombia.Therefore, the objective of this study is
The cellular pathology of schizophrenia and the potential of antipsychotics to target underlying neuronal dysfunctions are still largely unknown.We employed glutamatergic neurons derived from induced pluripotent stem cells (iPSC) obtained from schizophrenia patients with known histories of response to clozapine and healthy controls to decipher the
An imbalance in urban development in China has become a contradiction.Points of Interest (POIs) serve as representations of the spatial distribution of urban functions.Analyzing POI spatial co-occurrence patterns can reveal the agglomeration patterns of urban functions across cities at different levels, providing insights into imbalances in urban d
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties.Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant.Su